The RG421 features a mahogany body bolted to a maple Wizard III neck with a 24-fret rosewood fretboard with white dot position markers. Components include Ibanez pickups and a fixed bridge. An update for 2015 introduced new pickups and a one-piece neck. For 2018 the rosewood fretboard was replaced with jatoba. For 2019 the mahogany body was replaced with meranti. For 2020 the bridge was replaced with the F106.

Number of Strings6
Left-/Right-handedRight-handed
Body TypeSolidbody
Body ShapeRG421
Body MaterialMeranti
Top MaterialQuilted Maple
Body FinishOil
ColorMahogany Oil
Neck MaterialMaple
Neck ShapeWizard III
Neck JointBolt-on
Radius15.74"
Fingerboard MaterialJatoba
Fingerboard InlayDots
Number of Frets24
Scale Length25.5"
Nut Width1.692"
Nut MaterialPlastic
Bridge/TailpieceF106 Bridge
TunersIbanez
Neck PickupIbanez Quantum Humbucker
Bridge PickupIbanez Quantum Humbucker
Controls1 x volume, 1 x tone
Switching5-way blade pickup switch
Strings.010-.046
Case/Gig BagSold Separately

Ibanez RG421-MOL RG Standard Series Electric Guitar, Mahogany Oil